Frontline Spot On has a non-systemic mode of action. Frontline Spot-On kills parasites through contact, not via the pet's bloodstream.

From where you apply the product, Frontline Spot-On spreads all over the pet's body. It concentrates into the sebaceous glands of the skin and is constantly replenished over the pet's skin and coat. This 'store' gives the product its prolonged efficacy – even after bathing, swimming and grooming.

• Fast acting - Kills fleas within 24 hours and ticks within 48 hours.
• Long lasting - Kills fleas for up to 5 weeks in cats and up to 2 months in dogs. Kills ticks for up to a month in cats and dogs.
• Water resistant - Your pet can swim or be bathed as usual from 48 hours after application.

How Frontline Spot-on Works
FRONTLINE Spot-On kills fleas and ticks by affecting their nervous system. It causes hyperexcitation in these parasites. Disoriented, dying fleas rise to the surface of the pet's coat – which is why you might actually notice more fleas after applying the product.

Weigh your pet and choose the correct size pipette for its weight.
Applying Frontline Spot-On causes fleas to become hyperexcited, so it's not unusual for them to become more visible before dying. You can handle your cat or dog as usual as soon as the application site is dry.

Applying the First Dose
Buy the correct type of Frontline. You can purchase Frontline at a pet store or your vet's office. You also may be able to get Frontline at some drug stores, like CFC Healthcare. It's a good idea to buy Frontline from a vet, however, as a veterinarian can a make sure you get the right product.
•Frontline makes flea and tick treatments for dogs as well as cats. Make sure you use the medication designed for your pet.
•The dosages are sold according to the weight of the pet. Check the weight recommendations on the package and get a dosage appropriate for your pet's weight.

Remove the applicators. Frontline comes with several small plastic applicators. They look something like little bottles. Each applicator contains a single dose of Frontline.
•There are perforated lines between each applicator. You can separate the applicators by tearing or cutting along the perforated line.
•Be careful when separating the applicators. You want to make sure you do not tear an applicator and spill a dosage of Frontline.

Snap off the opening of the applicator. Each applicator has a small tip that you can easily snap off. You must snap off the tip prior to applying Frontline to your dog or cat.[3]
•Make sure to do this away from your face to avoid getting the chemicals in your eyes.
•If the tip does not come off easily, you can use scissors to cut it off.

Find a spot on your pet's back. You should apply Frontline on your pet's back, directly between your pet's shoulders. Frontline is safe to use on a pet's skin, but should not be ingested by the pet. Your pet will be unable to reach this area, preventing them from licking Frontline off.

Apply the Frontline to your pet's skin. Part your pet's fur so you can see its skin. This is very important. To work effectively, Frontline must be absorbed into your pet's skin. It must make direct contact with the skin, and not the fur, to do so.
•Place the tip of the applicator onto your pet's skin.
•Squeeze the vial and empty all of the liquid onto your pet's skin. Try to avoid getting any liquid on your pet's hair.


Caring for Your Pet Afterwards
Allow the medication to be absorbed on its own. Avoid rubbing the liquid in or spreading it around. It will absorb quickly on its own. You can let your pet go shortly after applying Frontline.
•If you get any Frontline on your hands, quickly wash your hands in soap and water.

Keep your pet dry for 48 hours*. You want to make sure Frontline is adequately absorbed into your pet's skin. Water can drain the oils from your pet's skin that are necessary to spread Frontline. Your pet should not get wet for 48 hours after you apply Frontline.
•Do not bathe your pet after applying Frontline. Frontline should be effective on its own to treat fleas and ticks. A flea bath or dip is not necessary.
•Do not let your cat or dog swim for 48 hours after applying Frontline. *New Upgraded Front line are Water resistant

Reapply Frontline as necessary. Frontline is effective for 8 weeks for dogs, and 6 weeks for cats. Mark on your calendar when you applied Frontline. Reapply Frontline at the 6- or 8-week mark.
•It's important to reapply Frontline regularly. Even if an infestation has cleared up, fleas and flea larvae may be present in your home. You want to make sure your cat or dog is continually protected from fleas and ticks.


Taking Safety Precautions
Read all of the instructions and warnings. This is a good precaution with any medication. You should not apply Frontline before reading the instructions manual.
•If your pet has any underlying health concerns, you should talk to a vet in addition to reading the instructions manual.

Make sure you use the correct type of Frontline for your pet. Frontline for dogs and cats are not the same product. Many people think they can be used interchangeably, but this is not the case. Make sure you do not use Frontline for dogs or cats or vice versa.
•If you accidentally used Frontline on the wrong type of pet, contact your vet immediately. Your pet could have an adverse reaction.
•If you want a product that can be used on both cats and dogs, look into Frontline spray.

Do not share applicators. Each applicator contains a single dose of Frontline. You should not share applicators between pets. If you do so, neither pet will get a full dose. This can prevent the product from working effectively.